Functional significance of the interaction between inducible costimulator (ICOS) and its ligand (ICOSL)
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چکیده
....................................................................................................... viii TABLE OF CONTENTS .......................................................................................xi LIST OF TABLES ............................................................................................... xiii LIST OF FIGURES ............................................................................................. xiv LIST OF ABBREVIATIONS .................................................................................xv INTRODUCTION .................................................................................................. 1 Costimulation via CD28and B7-family members ............................................. 1 ICOS: ICOSL Interaction ................................................................................... 3 Role of ICOS and ICOSL in SLE ....................................................................... 6 Reverse signaling identified for B7 family members ....................................... 12 Ectodomain Shedding ..................................................................................... 14 Hypothesis ...................................................................................................... 16 MATERIALS AND METHODS ............................................................................ 19 Reagents......................................................................................................... 19
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